Post on 25-Aug-2020
Engineering your health, utopia or reality, 2013 Bart Nuttin
In collaboration with: Exp. Functional Neurosurgery • J. Callemeyn • M. Deprez • Ph. De Vloo • S. Klein • K. Mols • K. van Kuyck • K. Vermeersch • H. Wu BioEngineering Dept • JM. Aerts • T. Tambuyzer
ESAT • F. Ceyssens • I. Gligorijevic • N. Koolen • B. Puers • S. Van Huffel • W. Wouters IMEC • Wolfgang Eberle, Dimiter
Prodanov, Silke Musa, Gustaaf Borghs, Marleen Welkenhuysen
Psychiatry • Loes Gabriëls • Simon Raemaekers • Elske Vrieze
Trauma
Trauma
electrode array for recording and stimulation on lesion cavity wall
Kris*na Vermeersch
Conformal, neural electrode array wrapped onto a model of the brain. The wrapping process occurs spontaneously, driven by capillary forces associated with dissolu;on of a thin, suppor;ng substrate of silk. John
Kim DH, Viven* J, Amsden JJ, Xiao J, Vigeland L, Kim YS, Blanco JA, Panilai*s B, FrecheAe ES, Contreras D, Kaplan DL, OmeneAo FG, Huang Y, Hwang KC, Zakin MR, LiA B, Rogers JA. Dissolvable films of silk fibroin for ultrathin conformal bio-‐integrated electronics, Nature Materials 2010, 9(6):511-‐7.
Conformal, neural electrode array wrapped onto the hemispherical ;p of a glass rod.
F. Ceyssens B. Puers
Flexible web electrode arrays • interconnected ‘islands’ • stretchable and flexible • 16 channels • insulated microwires • minimal thickness, insulation included:
2.5 µm • minimal width: 10 µm
F. Ceyssens B. Puers
Porous chitosan = resorbable carrier with good adhesion to CNS, haemostatic and antiseptic
Sheet of porous chitosan
Electrodes (ø 92 µm)
20 µm
F. Ceyssens B. Puers
Required : • Intense collabora*on between doctors – engineers, scien*sts -‐ industry
• Technological development (hardware and soaware)
• Signal analysis • Toxicity studies • Preclinical research • Finally apply in pa*ents
• It is a generic approach
Conclusion : Engineering your health, utopia or reality, 2013
• Engineering your health, reality in 2013 – Example : DBS in OCD
• May become reality – Example : brain cavi*es