Engineering your health, utopia or reality, 2013 Bart Nuttin

In collaboration with: Exp. Functional Neurosurgery •  J. Callemeyn •  M. Deprez •  Ph. De Vloo •  S. Klein •  K. Mols •  K. van Kuyck •  K. Vermeersch •  H. Wu BioEngineering Dept •  JM. Aerts •  T. Tambuyzer

ESAT •  F. Ceyssens •  I. Gligorijevic •  N. Koolen •  B. Puers •  S. Van Huffel •  W. Wouters IMEC •  Wolfgang Eberle, Dimiter

Prodanov, Silke Musa, Gustaaf Borghs, Marleen Welkenhuysen

Psychiatry •  Loes Gabriëls •  Simon Raemaekers •  Elske Vrieze

           Trauma                

   

           Trauma                

   

electrode array for recording and stimulation on lesion cavity wall

 

Kris*na  Vermeersch  

Conformal,  neural  electrode  array  wrapped  onto  a  model  of  the  brain.  The  wrapping  process  occurs  spontaneously,  driven  by  capillary  forces  associated  with  dissolu;on  of  a  thin,  suppor;ng  substrate  of  silk.  John  

Kim  DH,  Viven*  J,  Amsden  JJ,  Xiao  J,  Vigeland  L,  Kim  YS,  Blanco  JA,  Panilai*s  B,  FrecheAe  ES,  Contreras  D,  Kaplan  DL,  OmeneAo  FG,  Huang  Y,  Hwang  KC,  Zakin  MR,  LiA  B,  Rogers  JA.  Dissolvable  films  of  silk  fibroin  for  ultrathin  conformal  bio-­‐integrated  electronics,  Nature  Materials  2010,  9(6):511-­‐7.  

Conformal,  neural  electrode  array  wrapped  onto  the  hemispherical  ;p  of  a  glass  rod.    

F.  Ceyssens  B.  Puers    

Flexible web electrode arrays •  interconnected ‘islands’ •  stretchable and flexible •  16 channels •  insulated microwires •  minimal thickness, insulation included:

2.5 µm •  minimal width: 10 µm

F. Ceyssens B. Puers

Porous chitosan = resorbable carrier with good adhesion to CNS, haemostatic and antiseptic

Sheet of porous chitosan

Electrodes (ø 92 µm)

20 µm

F. Ceyssens B. Puers

Required  :  •  Intense  collabora*on  between  doctors  –  engineers,  scien*sts  -­‐  industry  

•  Technological  development  (hardware  and  soaware)  

•  Signal  analysis  •  Toxicity  studies  •  Preclinical  research  •  Finally  apply  in  pa*ents  

•  It  is  a  generic  approach  

 

Conclusion  :  Engineering  your  health,  utopia  or  reality,  2013  

•  Engineering  your  health,  reality  in  2013  – Example  :  DBS  in  OCD  

•  May  become  reality  – Example  :  brain  cavi*es