Séminaire 2 E-santé: diagnostic anatomo-pathologique.

Du projet BWB vers la pathologie digitale Wallonie-Bruxelles

Biothèque Wallonie-Bruxelles www.biotheque-wallonie-bruxelles.be

Laurent Dollé Operating manager

Sabine Cornelis Operating manager assistant

Agenda

Main tasks and current achievements

Perspectives and valorization

Main challenges we are facing

BWB Context : “biobanking”

BWB project

What is a Biobank?

Biological resources

What is a Biobank?

Patient/Clinic Biobank Discovery

Fabienne George

Myriam Remmelink

Flavienne Sandras

What is a Biobank?

Storage size Nature of

samples

What is a Biobank?

provides the provision of the human body material exclusively for scientific research and is not intended for human application

with high quality control and respecting the legal* & ethical framework

*Le biobanking est régi par la Loi du 19/12/2008, relative à l'obtention et à l'utilisation de matériel corporel humain destiné à des applications médicales humaines ou à des fins de recherche scientifique. Cette loi qui répond à la directive européenne de 2005, impose le passage obligé du matériel biologique humain destiné à la recherche scientifique par une biobanque de matériel corporel humain qui en assure la gestion depuis l'obtention du matériel jusqu'à son utilisation.

receives, stores, processes, disseminates biological specimens (blood, tissue, urine, saliva etc.)

ensures storage of associated data from human body material (medical, epidemiological,

molecular, physiological, structural…)

BWB context: “biobanking”

Doable Partially doable Non-manageable

Encompasses the physical location and the full range of operational activities

Professional staff and a commitment to maintain and preserve specimens and records

Fabienne George

Flavienne Sandras

BWB context: challenges in biobanking

Get access

Certified quality

Find samples PP dialogue

Time Filling out

forms

BWB context: challenges in biobanking

BWB context: why biobanking?

To participate in the development of new diagnostic, prognostic and predictive tests

To enable the development of new drugs

To improve treatment for patients

To identify patients predisposed to a disease

To predict the response of a patient to a drug

There is no longer biomedical research without biobanks

Dominique Demonte

BWB’s mission is dedicated to supporting biomedical research for the benefit of patients by providing high-quality

specimens and associated medical and molecular data compliant with international quality standards and regulations

BWB Project: mission

● Create and implement a network to unify and make accessible human materials and scientific data managed by the biobanks of

Wallonia-Brussels’ territory

● Promoting effective collaboration between academia and industry in a common goal to give and enhance value of such data

BWB operates on a decentralized model with:

1. A virtual network

2. A constitution of a virtual catalog 3. An offer of services to academic and industrial users with a front-office

BWB Project: objectives

Organizational component

Technical component

Valorization component

BWB project: structure

January 2014 – December 2017

2009

2012

3,4M€

Stakeholders of BWB project

Steering committee extended

Management team (Laurent Dollé, Sabine Cornelis, Nicolas

Pitance, Jean-Marc Hausman)

HUB ULB

HUB UCL

HUB CHU-Lg/ULg

5 biobanks 2 biobanks 1 biobank

University of Namur

University of Mons

1 biobank 1 biobank

Front-office= single-point of contact

Samples management

=

Decentralized approach

(Albert King Institute, Mont-Godinne)

(Jules Bordet, Brugmann- Brutus, CBEU-Erasme, IPG, ISPPC-Charleroi)

(BHUL)

Steering committee (Laurent Dollé, Isabelle Salmon,

Etienne Marbaix, Jacques Boniver)

Organizational component

Who is in charge?

Nicolas Pitance IT

Jean-Marc Hausman Jurist

Laurent Dollé Operating manager

Management

Sarah De Clercq Biobank manager assistant

Sabine Cornelis Operating manager assistant

Organizational component

Who ensures its governance?

Steering committee

Laurent Dollé Operating manager Prof. Isabelle Salmon Prof. Étienne Marbaix Prof. Jacques Boniver Xavier Hulhoven Didier Flagothier

Organizational component

1. Quality book 2. Ethic charter 3. HMTA 4. Constitution of workflow for request 5. Human samples request form 6. Price list

Harmonization of the documents with:

Current achievements Organizational

component

Virtual catalogue

Organizational component Current achievements

HUB

Meta-HUB Expertise, know-

how… Front-office

Front-office: modus operandi

Sample request

Virtual catalogue

Request processing

Delivery

Follow-up satisfaction

publications

collaboration

Biobankers

Researcher

Researcher

Analysis

Biospecimen

form

Quotation

Confidentiality contract

HMTA

Scientific committee

Ethical committee

Biobankers

Organizational component

Biospecimen

preliminary

request form

Presentation

of the request

Phone

call

Visit

on site

Round

table

Biospecimen

definite

request form

Mail

File

Current achievements Technical

component

Nicolas Pitance

71 experts

15 national nodes

509 biobanks

65 million of samples

10 experts

3 networks

13 biobanks

1,5 million of samples

Current achievements Valorization component

Current achievements Valorization component

Number of requests

0

10

20

2015

2016 N=20

Academia 15%

private 70%

public 15%

Nature of the request

n= 14

n= 3 n= 3

Belgium 45%

UK 20%

France 15%

US 5%

Germany 5%

Canada 5%

Others 5%

Nationalities

n= 9

n= 4

n= 3

Activity indicators – First rewards

Prospective 60%

Retrospective10%

Mix 30%

Type of collection

n= 2

n= 12

n= 6

Activity indicators – First rewards

0

2

4

6

8

10

12

public industrie

1

11

Public Private 0

0,5

1

1,5

2

2,5

3

académie industrie

3 3

Academy Private

0 2 4 6 8

Serum/plasma

FFPE

Frozen tissue

Fresh tissue

Sputum/BAL/OP/NP

Urine

Feces

Others

Number of request

Activity indicators – First rewards

0 5 10 15 20

demographic data

clinical data

diagnostic data

genomic data

analytical data

relapse

death date

survival duration

track down pregnancy data

lifestyle data

Nombre de demandes

Other services

TMA block TMA slide

FFPE tissue samples

TMA design TMA construction TMA validation

Sarah De Clercq

BWB offers new services: Tissue Microarrays (TMAs) Digital pathology

Isabelle Salmon

Guilhem Mascré

Christine Decaestecker

Establish & reinforce the front-office

Continue harmonization of common procedures (HMTA, road book,

white book, application form, setting up tracking of demands…)

Scalable maintenance of the IT platform

Enrich the virtual catalog

Get full range of expertise

Be opened to partnerships, conventions, collaborations

Enrich the pipeline of the BWB

Perspectives & valorisation

Broad consent vs. specific consent

Empower & enrich the success stories

Determine Key Performance Indicators

Economics and sustainability

Stimulate the valorisation of the prospective collections

Legislation is evolving, new rules, new norms & new obligations

Continuity of integrating small biobanks into the network

Main challenges

Privacy, confidentiality (data security) vs. data sharing

A clear understanding of the expectations/needs of industry/academy

Alone we are smart, together we are brilliant!

Laurent Dollé Operating manager

Laurent.Dolle@erasme.ulb.ac.be

Thank you for your time!