Pr Olivier Cussenot
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Transcript of Pr Olivier Cussenot
- 1. GENETIQUE & Cancers de la prostate O. CUSSENOT Urologie Hpital Tenon (AP-HP) / Universit Paris 6
2. Gntique et Cancers de la Prostate
- 1-Carcinogense
- 2-Aspects gntiques
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- Epidmio-gntique
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- Etudes familiales (linkage)
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- Etudes populationnelles (GWAS)
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- Etudes fonctionnelles
- 3-Applications & perspectives
3. 8 000 000 > 50 ans 80 000 CaP 100 Hommes 50 Cancers Histologiques de la Prostate 10 Cancers Cliniques de la Prostate 1 Dcs 5% Hrdit Mendlienne 15% Histoire familiale de CaP 80% Sporadiques 8 000 Epidmiologie & Facteurs de risque 4. Adnocarcinome Micro-invasif Cancer latent Cancer Evolutif Cancer Mtastatique & Rfractaire au Traitement Carcinogense Prostatique Croissance & maturation Prostatique Atrophie inflammatoireprolifrative Noplasieintrapithliale Prostate adulte Prdisposition gntique Hormones strodes Inflammation Stress oxydatif Enzymes et rcepteurs strodiens Rcepteurs macrophages, cytokines Carcinognes 1 2 3 5. CHAINON MANQUANT Prolifration Prolifration Prolifration Diffrentiation Carcinogense Prostatique AR DHT TMPRSS2 ETS AR TMPRSS2 ETS * - ETS AR DHT TMPRSS2 6.
- 1-La maladie
- 2-Aspects gntiques
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- Epidmio-gntique
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- Etudes familiales (linkage)
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- Etudes populationnelles (GWAS)
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- Etudes fonctionnelles
- 3-Applications & perspectives
7. How genetics can delimithigh risk groups for prostate cancer? Behind usual risk factors: Familial history of cancer & African origin Genetic markers of susceptibility 8. Segregation Dominant Autosomal --- X linked-- Recessive Predisposition locus 1956 1980 19961998200020062011Candidate GenesGenomewideassociation studies Markers of susceptibility Familial Prostate cancerA brief historyBRCA2 PCaP HPC1 8q24 9. Epidmio-gntique the Swedish Family-cancer database Czene et al, 2002 10. Bil-Axelson A et al. NEJM 2005 p