Exocytose

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    Egfpmtra 9 4 @axneytnsa#

    [ou`ftmnc ef`emqua ia `f caurntrfcslmssmnc#

    M# Mctrniuetmnc 4 uc pau igmstnrmqua#

    @f caurntrfcslmssmnc sahhaetua fu cmvafu ia sycfpsa '< znca ia enllucmeftmnc actra ;

    caurncas nu actra uc caurnca at uc luse`a pfr axalp`a-#

    Zgcnlca `aetrmquas at egmlmquas#

    Enceapt ia trfcslattaurs 4

    @axprmacea qum f parlms ia lattra ac vmiacea `f trfcslmssmnc egmlmqua < axprmacea

    iNttn @nawm#

    Qtm`msa ; eurs imhhracts kfmocfct ifcs euva ia `mqumia pgysmn`nomqua#

    6 eur mccarv pfr snc carh vfoua

    6 eur msn` ia snc carh vfoua

    Eas ; eurs snct rfeenris `fmia iuca pnlpa#

    @a ;la eur ast parhus pfr `a `mqumia pgysmn`nomqua prnvacfct iu 6areur#

    Ygnrmqualact 4

    Nc pacsa qua `a lassfoar ast `mkr ifcs `a `mqumia pgysmn`nomqua 6 at ast trfcslms ifcs `a

    `mqumia pgysmn`nomqua ; pums ifcs `a eur ; orea fux pnlpas#

    Nksarvftmncs 4

    Utmlu`ftmnc iu carh vfoua rf`actmssalact ia hrquacea efrimfqua#

    Nc nksarva of`alact uc rf`actmssalact ia `f hrquacea efrimfqua iu ;la eur#

    Zrsacea iuc lassfoar imhhusmk`a `mkr fu cmvafu iuca sycfpsa#

    @f `mkrftmnc iuc CY iuca stmlu`ftmnc prsycfptmqua paut tra sumva qufu trfvars ia snc

    ahhat pnst,sycfptmqua#F ratacmr of`alact 4 m` axmsta ias sycfpsas `aetrmquas#

    MM# @f sycfpsa 4 vmiaceas pnur uca `mkrftmnc qufctmqua 4 `axneytnsa#

    @as CY snct stnebs ifcs ias vsmeu`as sycfptmquas at snct `mkrs pfr axneytnsa# Ei pfr

    husmnc ia patmts enlpfrtmlacts lalkrfcfmras 'vsmeu`as nu orfcu`as- fvae `f lalkrfca

    p`fslmqua#

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    Vua``as snct `as vmiaceas >

    $ Avmiacea hncetmncca``a 4 `mkrftmnc qufctf`a#

    < `mkrftmnc pfr qufctf '6 qufctf < 6 vsmeu`a-#

    Acraomstralact ia pntactma` ia p`fqua lntrmea 'ZZL- < vfrmftmnc ia pntactma` acraomstr fu

    cmvafu ia `f tarlmcfmsnc pnst,sycfptmqua fu cmvafu iuca dncetmnc caurnluseu`fmra# Eatacraomstralact < rah`at ia `f `mkrftmnc iu CY#

    Fu cmvafu ia `f p`fqua lntrmea 4 Fety`egn`mca fvae uc reaptaur cmentmcmqua#

    Nc stmlu`a `a lntncaurnca `aetrmqualact nc acraomstra uca orfcia vfrmftmnc ia pntactma`

    Enllact hfmra pnur lasurar `f qufctmt ia ln`eu`as ia CY.vsmeu`a >

    Nc utm`msa `f lmernmnctnpgnrsa#

    Qca `aetrnia ifcs `fqua``a nc lat uca enceactrftmnc enccua iFeg 'nu iuc futra CY-# Eatta

    `aetrnia ast nuvarta nc `fpprnega ia `f tarlmcfmsnc pnst sycfptmqua n m` y f `as reaptaurs

    cmentmcmquas#

    Nc f vf`u qua 4

    6 qufctul iFEg < 6 pfquat iacvmrnc 6: ::: ln`eu`as#

    Acvmrnc 1:: lln`a#@,6 iFEg ifcs uca vsmeu`a#

    Ax 4

    Fpp`mqua Feg 6::lL

    seglf ;#Nc hfmt pfssar uc enurfct `aetrmqua ifcs ``aetrnia at `Feg ast `mkra at vf sa hmxar sur sas

    reaptaurs#

    Vua` ast `flp`mtuia iu ZZLL `nrsqua `Feg ast `mkra spnctfclact >

    Nc enlpfra `a rsu`tft nktacu fvae uca enurka axprmlactf` rf`msa pfr lmernmnctnpgnrsa#

    Ence`usmnc nc f vf`u qua 4

    6 qufctul iFEg < 6 pfquat iacvmrnc 6: ::: ln`eu`as#

    Acvmrnc 1:: lln`a#@,6 iFEg ifcs uca vsmeu`a#

    @as tuias fu lmernsenpa `aetrncmqua nct hnurcm `f cntmnc ia qufctf uc suppnrt

    lnrpgn`nomqua 4 prauvas ia `f `mkrftmnc vsmeu`fmra#

    6ra prauva 4

    Ifcs uca tarlmcfmsnc pnst,sycfptmqua m` y f tnudnurs ias vsmeu`as ia lla tfm``a acvmrnc#

    @f sycfpsa ast ralp`ma ia vsmeu`as sycfptmquas#

    F `f dncetmnc caurnluseu`fmra `as vsmeu`as sycfptmquas sf`mocact fu cmvafu ia zncas fetmvas

    pr,sycfptmquas prtas husmnccar#

    ;la vmiacea 4

    Nc vnmt `as vsmeu`as 'nu orfcu`as- husmnccar sur `f lalkrfca p`fslmqua# 'Nc nksarva ias

    hmouras ac nlof-#

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    5la vmiacea 4

    Yaegcmquas ia erynhrfetura#

    Nc p`ncoa uc egfctm``nc ifcs uc lm`mau trs hrnmi 'trs krutf`alact- at nc efssa `egfctm``nc#

    Unuvact `egfctm``nc sa efssa actra `as ; haum``ats 'acirnmt `a " hrfom`a-#

    Zarlat ia vnmr `as haum``ats ia `f lalkrfca#

    A < aetnp`fslmqua Z < prntnp`fsta

    Nc nksarva ias trnus `acirnmt n m` y fvfmt ias prntmcas#

    At nc nksarva ias prntmcas ia prnhusmnc < qum ipfssact#

    Nc nksarva of`alact uc f`mocalact ia pfrtmeu`as `nrsqua `f sycfpsa cast pfs stmlu`a#

    Fprs stmlu`ftmnc `aetrmqua tnudnurs f`mocalact ia pfrtmeu`as " m` y f ias trnus ifcs `f

    lalkrfca fppa`s pumts 'nu pnras ia husmnc-#Eas pumts enrraspnciact fux pnras hnrls `nrs ia `f husmnc ias vsmeu`as#

    seglf 5#

    MMM#Axneytnsa encstmtutmva vs axneytnsa encstmtutmva#

    Nc imstmcoua ; typas iaxneytnsa 4

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    encstmtutmva < iua ias vsmeu`as sa hnrlfct iapums `a rsafu trfcson`omac# A``as snct

    firassas vars `f lalkrfca p`fslmqua# Ea qum efrfetrmsa eatta vnma east qua``a

    sahhaetua ocrf`alact vmtassa encstfcta# Enlla east uc prneassus parlfcfct nc

    cnksarva pfs ia stneb ia eas vsmeu`as# F pnur hncetmnc prmcempf`alact 4 `a

    racnuva``alact ias encstmtufcts lalkrfcfmras at `a racnuva``alact ia `f lftrmea

    axtrfea``u`fmra# @f vmtassa iaxneytnsa cast pfs rou`a# Ea prneassus ast rou`ucmqualact pfs `f vmtassa ia syctgsa prntmqua# Lefcmsla ucmvarsa`#

    [ou`a < ias vsmeu`as knuroanccact iu rsafu trfcson`omac# Nc trnuva ias stnebs ia

    vsmeu`a# @as stnebs sa trnuvact ifcs `f znca fetmva pnur uca sycfpsa# Eas stnebs vnct

    fttacira uc smocf` 'ax 4 hmxftmnc iuca gnrlnca sur uc reaptaur lalkrfcfmra-#

    [ou`ftmnc ia `axneytnsa at ince ia `f vmtassa ia `mkrftmnc pfr ias lassfoars

    mctrfea``u`fmras# Lefcmslas cnc ucmvarsa m` ast enlluc imhhracts typas ia

    ea``u`as 4

    , Caurncas CY

    , Acinermcas gnrlncas paptmimquas

    , Axnermcas `mkrftmnc iaczylas imoastmvas

    , Lfstneytas gmstflmca

    Fu enurs ia `axneytnsa `as vsmeu`as knuroanccact iapums `a rsafu trfcson`omac cntfllact

    orea `f prsacea ia prntmcas enftflras 'enft 6 enft ; at e`ftgrmca- nc nktmact ias

    vsmeu`as mllfturas < vsmeu`as ia orfcia tfm``a n `a lftrma` mctarca ast pau enciacs# Fu

    hur at lasura ia `f lmorftmnc vars `f lalkrfca m` y f uc pgcnlca ia lfturftmnc fvae

    enciacsftmnc iu lftrma` trfcspnrt# M` y f of`alact uca lfturftmnc kmnegmlmqua#

    Ea snct eas vsmeu`as lfturas qum vnct pnuvnmr husmnccar fvas `f lalkrfca p`fslmqua at pfs

    `as futras#

    Zn`frmsftmnc ias lefcmslas ia `axneytnsa 4

    @as lefcmslas iaxneytnsa pauvact tra pn`frmss#

    K# Nc mciumt `axneytnsa a``a sa prniumt pfrtnut ifcs `f ea``u`a#

    E# @axneytnsa cast ie`acega qua iu et ia `foact stmlu`fct# Axneytnsa pn`frmsa lla

    sur uca ea``u`a cnc pn`frmsa#

    M` paut fussm y fvnmr uca pn`frmsftmnc lnrpgn`nomqua# Ax 4 ea``u`as pmtg`mf`as#

    Vuast ea qum hfmt qua `as vsmeu`as snct nrmactas vars `a p`a fpmef` nu vars `a p`akfsn`ftrf` >

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    Ias squaceas prntmquas ifcs `as lalkrfcas ias vsmeu`as parlattact iacvnyar eartfmcas

    vsmeu`as spemhmqualact vars `a p`a fpmef` nu vars `a p`a kfsn`ftrf`#

    Ax 4 Umocfux 4 prsacea iuca tyrnsmca at . nu prsacea ia `auemcas itarlmca `nrmactftmnc

    vars `a p`a kfsn`ftrf`#

    Fu cmvafu fpmef` `as vsmeu`as emk`as vars `a p`a fpmef` enctmaccact ias prntmcas fcerfoa

    OZM 'O`yensy` Zgnspgftmiy` Mcnsmtn`-# @a ornupalact OZM parlat `f prntmca ia sfcerar

    `f lalkrfca# @as vsmeu`as enctacfct eas ornupalacts OZM snct nrmactas vars `f lalkrfca

    fpmef`a#

    Xars `f lalkrfca kfsn`ftrf`a 4 smocfux ifcs `f tarlmcfmsnc eytnp`fslmqua# 6- smocf`

    enctacfct 6 tyrnsmca at ;- ; `auemcas fidfeactas#

    Eas femias flmcs snct raenccus pfr ias prntmcas enftflras qum `as fssalk`act ifcs ias

    vsmeu`as ia trfcspnrt fu cmvafu iu rsafu trfcs On`om#

    Yrfhme lalkrfcfmra ifcs `f sycfpsa 4

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    Enrps ea``u`fmra " sycfpsa 'enup pnur lam``aura vmsuf`msftmnc-#

    Ias vsmeu`as sa hnrlact at vnct tra nrmactas vars `f lalkrfca p`fslmqua#

    F pfrtmr iu rsafu trfcson`omac nc paut fvnmr ias lefcmslas iaxneytnsa encstmtutmva at ias

    lefcmslas iaxneytnsa rou`a 'pnur `as caurnpaptmias at cnc `as CY-#

    @as vsmeu`as qum parlattact `f `mkrftmnc ia CY prnvmaccact ias acinsnlas# Eas acinsnlas

    parlattact `a knuroanccalact ia vsmeu`as sycfptmquas# Ifcs uc 6 ar talps `as vsmeu`as snct

    vmias# Zums a``as snct ralp`mas at vnct pnuvnmr f`nrs husmnccar pfr axneytnsa# Lfturftmnc

    A``a inmt fomr sur uc reaptaur.sacsaur.ahhaetaur#

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    Umta ia hmxftmnc enup` uc `lact ia rpncsa#

    [pncsa pgysmn`nomqua 'enctrfetmnc sertmnc-

    Uf enceactrftmnc inmt egfcoar ia lfcmra smocmhmeftmva ac rpncsa uc futra smocf`#

    Uystla pnur erftmnc at iastruetmnc iu lassfoa#

    Cmvafu iu saenci lassfoar inmt egfcoar ac rpncsa uc stmlu`us cftura` at eaem

    fvfct at pacifct qua `f ea``u`a rpnci#Ef`lniu`mca sacsaur Ef;"#

    Zrntmca bmcfsa F sacsaur FLZe#

    X# @a ef`emul enlla saenci lassfoar#

    @a ef`emul paut ractrar pfr ias efcfux mncmquas at ast efpfk`a ia ie`acegar `axneytnsa#

    Lfms `axneytnsa ast ipacifct iu eytnsqua`atta at `a ef`emul mctarvmact sur ia cnlkrausas

    prntmcas iu eytnsqua`atta#

    @a ef`emul fomt imhhracts cmvafux#

    Axneytnsa at ;ci lassfoars 4 @a ef`emul stmlu`a `f sertmnc rou`a#

    Nc paut egfcoar `f enceactrftmnc ac ef`emul `axtrmaur ia `f ea``u`a# Enllact paut,nc

    f``ar enctr`ar `f enceactrftmnc ac ef`emul `mctrmaur ia `f ea``u`a >Nc paut utm`msar uc itaroact inux qum vf hfmra ias patmts trnus ifcs `f lalkrfca