BIOmem Glucose sensor Une belle histoire…. - Concept -- Clark (1956) - Concept -- Clark (1956) -...
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Transcript of BIOmem Glucose sensor Une belle histoire…. - Concept -- Clark (1956) - Concept -- Clark (1956) -...
- Concept -- Clark (1956)- Concept -- Clark (1956)
- Enzyme electrode -- Lyons and Clark (1962)- Enzyme electrode -- Lyons and Clark (1962)
HISTORY OF BIOSENSORS
- Concept -- Lyons and Clark (1956)- Concept -- Lyons and Clark (1956)
- Enzyme electrode -- Lyons and Clark (1962)- Enzyme electrode -- Lyons and Clark (1962)
- Glucose Analyser -- Yellow Springs Instr. Co. - Glucose Analyser -- Yellow Springs Instr. Co. (1973)(1973)
HISTORY OF BIOSENSORS
• Peroxide sensor: [H2O2] current
Glucose Gluconic acid
Oxygen Hydrogen Peroxide O2 H2O2
Glucose Oxidase
1975 : YSI 23A Blood Glucose AnalyzerFirst whole blood glucose analyzer (YSI, USA)
1982 : YSI 2300 STAT Plus Glucose & Lactate Analyzer
Glucose analyseur commercialisé par YELLOW SPRINGS Instr. Co.
- Concept -- Lyons and Clark (1956)- Concept -- Lyons and Clark (1956)
- Enzyme electrode -- Lyons and Clark (1962)- Enzyme electrode -- Lyons and Clark (1962)
- Glucose Analyser -- Yellow Springs Instr. Co. - Glucose Analyser -- Yellow Springs Instr. Co. (1973)(1973)
- Enzyme Electrode – MediSense Inc. (1987)- Enzyme Electrode – MediSense Inc. (1987)
HISTORY OF BIOSENSORS
• Mediator (ferrocene) e- current
Glucose Gluconic acid
Oxygen Hydrogen Peroxide O2 H2O2
Glucose Oxidase
1983 : Glucose capteur avec médiateur électrochimique
Glucose Gluconic acid
GOD-FAD GOD-FADH2
Ferricinium Ferrocene
1 e-
RFe
+R
Fe
THE MEDISENSE* EXACTECH™ GLUCOSE biocapteur pour le sang
*MediSense is now owned by AbbottSince 1996 (867 million $)
WalMart ReliOn™ (MediSense ™)
2005 : GlucoWatch G2 (Cygnus Inc., USA) : based on electroosmosis and electrochemical measurement of interstitial fluid
Evolution récente : système non invasif
GLUCOSE
SENSOR
Market opportunity
-Diabetus
Biology -Glucose oxidase
Instrumentation-portable
Electronics-data processing
Chemistry-polymers-electrode materials-mediators