0602 system 2 google otenzielle Nutzenbeitrag für das Unterne

[48] Zhu W, Rawlins BA, Boachie-Adjei O, et al. Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic dif- ferentiation and spine fusion in a rodent model. J Bone Mineral Res 2004;19:2021–32. [49] Cunningham BW, Kotani Y, McNulty PS, Cappuccino A, Kanayama M, Fedder IL, McAfee PC. Video-assisted thoracoscopic surgery versus open thoracotomy for anterior thoracic spinal fusion: a comparative radiographic, biomechanical, and histologic analysis in a sheep model. Spine 1998;23:1333–40. [50] Cook SD, Dalton JE, Tan EH, Whitecloud TS 3rd, Rueger DC. In vivo evaluation of recombinant human osteogenic protein (rhOP-1) implants as a bone graft substitute for spinal fusions. Spine 1994;19: 1655–63. [51] Magin MN, Delling G. Improved lumbar vertebral interbody fusion using rhOP-1: a comparison of autogenous bone graft, bovine hydroxylap- atite (Bio-Oss), and BMP-7 (rhOP-1) in sheep. Spine 2001;26:469–78. [52] Boden SD, Titus L, Hair G, et al. Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP- 1). Spine 1998;23:2486–92. [53] Boden SD, Martin GJ Jr, Morone MA, Ugbo JL, Moskovitz PA. Posterolateral lumbar intertransverse process spine arthrodesis with recombinant human bone morphogenetic protein 2/hydroxyapatite- tricalcium phosphate after laminectomy in the nonhuman primate. Spine 1999;24:1179–85. [54] Hidaka C, Goshi K, Rawlins B, Boachie-Adjei O, Crystal RG. En- hancement of spine fusion using combined gene therapy and tissue engineering BMP-7-expressing bone marrow cells and allograft bone. Spine 2003;28:2049–57. [55] Wang JC, Kanim LEA, Yoo S, Campbell PA, Berk AJ, Lieberman JR. Effect of regional gene therapy with bone morphogenetic protein-2- producing bone marrow cells on spinal fusion in rats. J Bone Joint Surg 2003;85-A:905–12. [56] Bomback DA, Grauer JN, Lugo R, Troiano N, Patel TC, Friedlaender GE. Spine 2004;29:1612–7. [57] Jhu W, Rawlins BA, Boachie-Adjei O, et al. Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differen- tiation and spine fusion in a rodent model. J Bone Mineral Res 2004;19:2021–32. 45 Years Ago in Spine A method for restructuring images of soft tissues from measurements of discontinuities of radiodensity was described by William Henry Oldendorf in 1961 [1]. Improvements led, 14 years later, to Sir Godfrey Hounsfield’s description of computer assisted tomography [2], for which Hounsfield received the 1979 Nobel Prize for Medicine. References [1] Oldendorf WH. Isolated flying spot detection of radiodensity discontinuities displaying the internal structural pattern of a complex object. IRE Trans Bio-med Electron 1961;8:68–72. [2] Hounsfield GN. Computerized transverse axial scanning (tomography). Br J Radiol 1975;46:1016–22. 67 R.D. Rao / The Spine Journal 7 (2007) 61–67

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Wie gut lässt sich der Nutzen dieses Anwendungsfalls planen? Nutzen Wie groß ist der potenzielle Nutzenbeitrag für das Unternehmen? Anwendungsfall Interne Communities Persönliches Informationsmanagement Projekte und Prozesse 4 Information und offizielle Kommunikation Interne Communities Was macht man damit? − Austauschgruppen – unabhängig von organisatorischen Strukturen − Viele Anwendungsmöglichkeiten wie Ideenmanagement, Frage an die Organisation oder Experten-Communities − Teilnahme basiert vor allem auf intrinsischer Motivation − Engagement in Communities ist meist nicht Teil der Stellenbeschreibung oder Ziel

Transcript of 0602 system 2 google otenzielle Nutzenbeitrag für das Unterne

Page 1: 0602 system 2 google otenzielle Nutzenbeitrag für das Unterne

[48] Zhu W, Rawlins BA, Boachie-Adjei O, et al. Combined bone mor-

phogenetic protein-2 and -7 gene transfer enhances osteoblastic dif-

ferentiation and spine fusion in a rodent model. J Bone Mineral

Res 2004;19:2021–32.

[49] Cunningham BW, Kotani Y, McNulty PS, Cappuccino A,

Kanayama M, Fedder IL, McAfee PC. Video-assisted thoracoscopic

surgery versus open thoracotomy for anterior thoracic spinal fusion:

a comparative radiographic, biomechanical, and histologic analysis in

a sheep model. Spine 1998;23:1333–40.

[50] Cook SD, Dalton JE, Tan EH, Whitecloud TS 3rd, Rueger DC. In

vivo evaluation of recombinant human osteogenic protein (rhOP-1)

implants as a bone graft substitute for spinal fusions. Spine 1994;19:

1655–63.

[51] Magin MN, Delling G. Improved lumbar vertebral interbody fusion us-

ing rhOP-1: a comparison of autogenous bone graft, bovine hydroxylap-

atite (Bio-Oss), and BMP-7 (rhOP-1) in sheep. Spine 2001;26:469–78.

[52] Boden SD, Titus L, Hair G, et al. Lumbar spine fusion by local gene

therapy with a cDNA encoding a novel osteoinductive protein (LMP-

1). Spine 1998;23:2486–92.

[53] Boden SD, Martin GJ Jr, Morone MA, Ugbo JL, Moskovitz PA.

Posterolateral lumbar intertransverse process spine arthrodesis with

recombinant human bone morphogenetic protein 2/hydroxyapatite-

tricalcium phosphate after laminectomy in the nonhuman primate.

Spine 1999;24:1179–85.

[54] Hidaka C, Goshi K, Rawlins B, Boachie-Adjei O, Crystal RG. En-

hancement of spine fusion using combined gene therapy and tissue

engineering BMP-7-expressing bone marrow cells and allograft bone.

Spine 2003;28:2049–57.

[55] Wang JC, Kanim LEA, Yoo S, Campbell PA, Berk AJ, Lieberman JR.

Effect of regional gene therapy with bone morphogenetic protein-2-

producing bone marrow cells on spinal fusion in rats. J Bone Joint

Surg 2003;85-A:905–12.

[56] Bomback DA, Grauer JN, Lugo R, Troiano N, Patel TC,

Friedlaender GE. Spine 2004;29:1612–7.

[57] Jhu W, Rawlins BA, Boachie-Adjei O, et al. Combined bone morpho-

genetic protein-2 and -7 gene transfer enhances osteoblastic differen-

tiation and spine fusion in a rodent model. J Bone Mineral Res

2004;19:2021–32.

67R.D. Rao / The Spine Journal 7 (2007) 61–67

45 YearsAgo in Spine

A method for restructuring images ofsoft tissues from measurements of discontinuities of ra-diodensity was described by William Henry Oldendorf

in 1961 [1]. Improvements led, 14 years later, to SirGodfrey Hounsfield’s description of computer assistedtomography [2], for which Hounsfield received the1979 Nobel Prize for Medicine.

References

[1] Oldendorf WH. Isolated flying spot detection of radiodensity dis-

continuities displaying the internal structural pattern of a complex

object. IRE Trans Bio-med Electron 1961;8:68–72.

[2] Hounsfield GN. Computerized transverse axial scanning (tomogra-

phy). Br J Radiol 1975;46:1016–22.