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16 décembre 2016

« Effets des ac7vités physiques adaptées sur les comportements sociaux co-verbaux dans la

schizophrénie : Étude préliminaire »

Dr.DEL-MONTEJonathanMaîtredeConférencesenPsychologieClinique

etPsychopathologieTCCE,UniversitédeNîmes

ÉlodieCharbonnier,PierluigiGraziani,LudovicMarin,&JéromeA=al

Lacommunica*onhumaine

«Ensembledesprocessusphysiquesetpsychologiquesparlesquelss’effectuelamise

en relaGon d’un ou plusieurs individus avec un ou plusieurs individus en vue

d’a=eindrecertainsobjecGfs»(Anzieu&MarGn,1968)

Comportementsmoteursco-verbaux:

• Gestesdesmains

• Contactsvisuels• SouriresTransfertsd’informaLonsetApprenLssages

(Broaders&Goldin-Meadow,2010)

Comportementsmoteursnon-verbaux:

• CoordinaLonsmotricesinterpersonnelles

IndispensablesàlaqualitédesinteracLonssociales(Schmidt&Richardson,2008)

CohésionetaffiliaLonsociale(Lakin&Chartrand,2003)

Lacommunica*onhumaine

SymptômesposiLfs SymptômesnégaLfs

Caractériséspar:

• Posturesanormales(Mi=aletal.,2011)

• SignesNeurologiquesMineurs(Neelametal.,2011)

• DiminuLondesgestesco-verbaux(Del-Monteetal.,2013)

Lapathologieschizophrénique

CAINS can be used with a single endpoint that reflects combined negative symp-tom severity across both these domains.Despite these potential limitations, the advances provided by both the theoretical

and psychometric development of the CAINS make it an important advance in ourfield. The development of instruments like the CAINS, motivated by findings fromaffective neuroscience, allow our field to stay abreast of advances in the basic sci-ences and pave the way for a more rationally informed approach to treatmentdevelopment, hopefully leading to more effective treatments for the debilitatingnegative symptoms of schizophrenia.

References

1. Tamminga CA, Buchanan RW, Gold JM: The role of negative symptoms and cognitive dysfunction inschizophrenia outcome. Int Clin Psychopharmacol 1998; 13(suppl 3):S21–S26

2. Andreasen NC: Negative symptoms in schizophrenia: definition and reliability. Arch Gen Psychiatry 1982; 39:784–788

3. Kirkpatrick B, Fenton WS, Carpenter WT Jr, Marder SR: The NIMH-MATRICS consensus statement on negativesymptoms. Schizophr Bull 2006; 32:214–219

4. Kring AM, Gur RE, Blanchard JJ, Horan WP, Reise SP: The Clinical Assessment Interview for Negative Symp-toms (CAINS): final development and validation. Am J Psychiatry 2013; 170:165–172

5. Schultz W: Multiple dopamine functions at different time courses. Annu Rev Neurosci 2007; 30:259–2886. Berridge KC, Robinson TE, Aldridge JW: Dissecting components of reward: “liking,” “wanting,” and learning.

Curr Opin Pharmacol 2009; 9:65–737. Ventura J et al: Brief Psychiatric Rating Scale (BPRS) expanded version: scales, anchor points, and adminis-

tration manual. Int J Methods Psychiatr Res 1993; 3:227–2438. Kay SR, Fiszbein A, Opler LA: The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr

Bull 1987; 13:261–2769. Kirkpatrick B, Strauss GP, Nguyen L, Fischer BA, Daniel DG, Cienfuegos A, Marder SR: The Brief Negative

Symptom Scale: psychometric properties. Schizophr Bull 2010; 2011; 37:300–30510. Strauss GP, Keller WR, Buchanan RW, Gold JM, Fischer BA, McMahon RP, Catalano LT, Culbreth AJ, Carpenter

WT, Kirkpatrick B: Next-generation negative symptom assessment for clinical trials: validation of the BriefNegative Symptom Scale. Schizophr Res 2012; 142:88–92

DEANNA M. BARCH, PH.D.

From the Departments of Psychology, Psychiatry, and Radiology, Washington University in St. Louis. Addresscorrespondence to Dr. Barch (dbarch@artsci.wustl.edu). Editorial accepted for publication October 2012 (doi:10.1176/appi.ajp.2012.12101329).

Dr. Barch reports no financial relationships with commercial interests.

FIGURE 1. The Two Dimensions of the Clinical Assessment Interview for Negative Symptoms (CAINS)

The Clinical Assessment Interview forNegative Symptoms (CAINS)

Expression Motivation/Pleasure

GesturesVocalprosody

Facial Speech RecreationExpected pleasurePast-week pleasureMotivation

VocationalExpected pleasureMotivation

SocialExpected pleasurePast-week pleasureFriendshipsFamily relationshipsMotivation

Am J Psychiatry 170:2, February 2013 ajp.psychiatryonline.org 135

EDITORIAL

(Barch,2012)

!  PathologiedesinteracLonssociales

•  Isolementsocial:premiersymptômedelaschizophrénie(Möller,2007)

•  RéducLonsignificaLvedesrelaLonssociales(Harleyetal.,2012;Giaccoetal.,2013)

•  FoncLonnementsocialaltérédansceVepathologiementale(Buchanan,2007;Grant&Beck,2009)

Lapathologieschizophrénique

Prisesenchargedestroublesdelacommunica*onco-verbale

! Tâched’amorçagesémanLqueimplicite:(Del-Monteetal.,2014)TâchedereconstrucLondephrasesconnotées:

•  Sociale(équipe,ensemble,groupe…)•  Neutre(voiture,arbre,banc…)

•  AnLsociale(seul,isolé,individuel…)

Prisesenchargedestroublesdelacommunica*onco-verbale

! Tâched’amorçagesémanLqueimplicite:(Del-Monteetal.,2014)

Figure 2. Total number of nonverbal behaviors. Schizophrenia patients (SZ) primed in pro-social condition and SZ primed in non-social andanti-social conditions were significantly different. SZ primed in non-social condition and SZ primed in anti-social condition were equivalent. Error barsrepresent standard deviations. * p,.05 and ** p,.001.doi:10.1371/journal.pone.0109139.g002

Figure 3. Subdimensions of nonverbal behavior. Significant differences were found between each comparison of patient groups. Error barsrepresent standard deviations.doi:10.1371/journal.pone.0109139.g003

Social Priming in Schizophrenia

PLOS ONE | www.plosone.org 5 October 2014 | Volume 9 | Issue 10 | e109139

Prisesenchargedestroublesdelacommunica*onco-verbale

Est ce qu’une acLvité écologique de coopéraLon peut induire une augmentaLon

significaLve de la communicaLon co-verbale au même Ltre que l’acLvaLon non

écologiqueduréseausémanLque?

Méthodologieexpérimentale

•  10paLentsaffectésdeschizophrénie

•  10paLentsaffectésdeschizophrénie

T0Motor-Affec*ve-Social-ScaleLilleApathyRaLngScalePANSS

T1Motor-Affec*ve-Social-ScaleLilleApathyRaLngScalePANSS

24Séancessur12semaines

Résultatspréliminaires

6,77

11,88

6,225,77

0

2

4

6

8

10

12

14

MASST0 MASST1

APA SansAPA

(p=0,008)

(p=0,001)

ScoresàlaM

ASS

•  ToM•  Empathie•  AffiliaLon•  Affects

•  Gestesdesmains•  Mimiquesfaciales

SLgmaLsaLon

(Brüneetal.,2009)

(Thornicrof,2009)

AffiliaLonsociale

(Baeetal.,2010)

(Bersanietal.,2012)(Comparellietal.,2013)(Lavelleetal.,2012)(Tsoetal.,2013)

(Delerue&Boucart,2013)(DelMonteetal.,2013)(Varletetal.,2012)

Discussion

(Del-Monteetal.,2014)

AffiliaLonsociale

Primingsocialimplicite

(Thornicrof,2009)

Ac*vitésphysiquesadaptées

Discussion

•  ToM•  Empathie•  AffiliaLon•  Affects

•  Gestesdesmains•  Sourires

SLgmaLsaLon(Salesseetal.,2014)

Cogni*onsituée

(Baeetal.,2010)

(Del-Monteetal.,2014)

Primingsocialimplicite

(Leightonetal.,2010)

•  ToM•  Empathie•  AffiliaLon•  Affects

•  Gestesdesmains•  Sourires

Ac*vitésphysiquesadaptées

Cogni*onincarnée

ProgrammesdePECclassiques

(Kurtzetal.,2012)(Kanekoetal.,2012)(Parkeretal.,2013)

Allerplusloin….

(Honnenlo=eretal.,2009)(Niedenthaletal.,2010)

MercipourvotreaVenLon

jonathan.del-monte@unimes.fr

!  AcLvitéssporLvesetsantémentale

•  Effetsbénéfiquessurlesépisodesdépressifsmajeurs(Perratonetal.,2010)

•  Effetsbénéfiquessurlessymptômesanxieux(Herringetal.,2010)

•  EffetsbénéfiquessurlestroublesbipolairesII(Wrightetal.,2009)

!  Schizophrénie

•  RéducLon des symptômes négaLfs (Duraiswamy et al, 2007; Acil et al., 2008;Pelhametal.,1993;Giminoetal.,1984)

•  RéducLondessymptômesposiLfs(Behereetal.,2010)

•  RéducLondesdéficitscogniLfs(Subramaniapillaietal.,2016)

!  AcLvitéssporLvesetschizophrénie

•  qualitédeviedespaLents(Duraiswamyetal.,2007;Aciletal.,2008;Behereetal.,2010)

•  ModificaLondelaplasLcitécérébrale(hippocampe)(Pajonketal.,2010)

•  RéducLondestroublesmétaboliques(Bernard&Ninot,2012)"  Obésité"  Cardiopathie"  DiabètedetypeII

!  Limite

•  Sportsindividuels