Charles Edouard Brown Sequard (1817- 1894)
Science 1997
& GH
GH-IGF1-Insulin
• 1- Les données de la recherche sont sans equivoque.
INSULIN / IGFs Signaling
KO GHKO GHRHKO GHRKO KO IGF1KO IGF1-RKO IRS 1 & 2, PI3 K
Yeasts, caenorhabditis elegans, insects, mice & centenarial model
INSULIN / IGFs Signaling
Endocrine Reviews 2011
Des taux bas d’IGF1 sont associés à une longévité accrue
• Déficit en GH• KO des récepteurs de la GH• KO des récepteurs de l’IGF1(Bartke A
Cur Top Dev Biol 63:189, 2004)
+ 18 %
GH-IGF1-Insulin
• 2- Chez l’homme…
Endocrine Reviews 2010, 31: 301-342.
JCEM 18: 901- 903, 1958
NATURE 1979
There is now a substantial body of evidence that indicates that GH Replacement Therapy has a beneficial effect upon many parameters:
Body composition improves, lean mass increases, and fat mass decreases sgnificantly.
-Fasting lipid profile improves with reduction on total cholesterol, LDL while HDL increases.
-GHT improves endothelial function as well as the markers of inflammation
- Carotid IMT also demonstrates a significant improvement during therapy
Swerdlow AJ, Higgins CD, Adlard P, Preece MA 2002 Risk of cancer in patients treated with17 human pituitary growth hormone in the UK, 1959-85: a cohort study. Lancet 360:273-277
-Insulin resistance is Increased
-There is no data demonstrating that GHT reduces cardiovascular mortality in hypopituitary adults
- In addition: cancer risk may be increased
HOWEVER
JCEM 2012
SAGhE : Safety and Appropriateness of Growth hormone treatments in Europe
Les Fondamentaux
• « Apprends d’hier, vis pour aujourd’hui, espère pour demain.
• L’important est de ne jamais arrêter de poser des question. »
Albert Einstein
www.ice-ece2012.com
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