1 EAPCI Board elections 2009 - Applications

Application for the following position in the

EAPCI Board: (Treasurer)

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YOUR IDENTITY

Name: DUBOIS-RANDE Jean-Luc Current Position: Professor of cardiolology, Head of the department of cardiology at Henri Mondor Hospital Country: France

Elections to the

European Association of Percutaneous Cardiovascular Interventions (EAPCI)

Board 2009-2011

2 EAPCI Board elections 2009 - Applications

GENERAL CV (300 words max)

- FELLOWSHIP: 1981-1985

- CARDIOLOGIST degree: 1985

- ASSISTANT IN CARDIOLOGY IN THE CARDIOLOGY DEPARTMENT OF HENRI

MONDOR HOSPITAL, 1985-1989

- ASSOCIATE PROFESSOR IN THE CARDIOLOGY DEPARTMENT OF HENRI

MONDOR HOSPITAL, 1990-1994

- PHD IN 1990 (PhD): NEUROTRANSMISSION IN HEART FAILURE

- PROFESSOR OF CARDIOLOGY since 1994

- HEAD OF THE DEPARTMENT since 2000

I have been working as interventionist for more than 20 years and I participated in the

development of different tools in this field as laser with Pr Geshwind, left ventricular

assistance during high risk PCI and I am involved in the different main studies

concerning devices or drugs in this field. I participated with M Kern to the development

of coronary physiology in the setting of PCI by assessing stenosis with Doppler and

pressure’s wires.

Besides clinical research, I participate to basic research in the field of endothelial

function, cardio protection and more recently cell therapy.

I am involved in the teaching of interventional cardiology. I launched the training

university program in interventional cardiology in France (Diplôme Interuniversitaire)

and I am still fully engaged in the teaching committee. More recently I participated to

the writing of the European teaching program (curriculum) with Pr Carlo Di Mario

published in Euro Intervention.

Reviewer in different journals: Interventional journal of Cardiology, European Heart

Journal, JACC, Circulation, European Journal of Heart Failure.

Besides interventional cardiology, I am involved in different heart failure groups

(national and European). Main field of expertise: ventricular assistance

Publications: more than 200 in Pubmed (Dubois-Rande JL and Rande JL)

Treasurer of 2 French associations and 1 foundation, previous treasurer of ESAC

(European group for aldosterone)

3 EAPCI Board elections 2009 - Applications

Previous experience in EAPCI, ESC or your National Bodies?

Writing of the curriculum in interventional cardiology Speaker for the European Society of Cardiology, at EuroPCR, and for the European Association of Echocardiography Chairman in different European congresses and in different national congresses Animal training program (labelled EBAC): for PFO closure, Coronary circulation

assessment (animal lab in Henri Mondor)

4 EAPCI Board elections 2009 - Applications

Publications (please list 10 max)

Loisance D, Dubois-Rande JL, Deleuze P, Okude J, Rosenval O, Geschwind H. Prophylactic intraventricular pumping in high-risk coronary angioplasty. Lancet. 1990;335:438-40.

Merlet P, Delforge J, Syrota A, Angevin E, Maziere B, Crouzel C, Valette H, Loisance D, Castaigne A, Rande JL. Positron emission tomography with 11C CGP-12177 to assess beta-adrenergic receptor concentration in idiopathic dilated cardiomyopathy. Circulation. 1993;87:1169-78.

Larrazet FS, Dubois-Rande JL, Dupouy PJ, Hirosaka A, Kvasnicka J, Geschwind HJ. Angioscopy after laser and balloon coronary angioplasty. J Am Coll Cardiol. 1994;23:1321-6. Perchet H, Dupouy P, Duval-Moulin AM, Hittinger L, Pelle G, Brun P, Castaigne A, Geschwind H, Dubois-Rande JL. Improvement of subendocardial myocardial perfusion after percutaneous transluminal coronary angioplasty. A myocardial contrast echocardiography study with correlation between myocardial contrast reserve and Doppler coronary reserve. Circulation. 1995;91:1419-26.

Aptecar E, Dupouy P, Benvenuti C, Mazzucotelli JP, Teiger E, Geschwind H, Castaigne A, Loisance D, Dubois-Rande JL. Sympathetic stimulation overrides flow-mediated endothelium-dependent epicardial coronary vasodilation in transplant patients. Circulation. 1996;94:2542-50.

Kern MJ, Puri S, Bach RG, Donohue TJ, Dupouy P, Caracciolo EA, Craig WR, Aguirre F, Aptecar E, Wolford TL, Mechem CJ, Dubois-Rande JL. Abnormal coronary flow velocity reserve after coronary artery stenting in patients: role of relative coronary reserve to assess potential mechanisms. Circulation 1999; 100: 2491-8 Garot P, Pascal O, Simon M, Monin JL, Teiger E, Garot J, Gueret P, Dubois-Rande JL. Impact of microvascular integrity and local viability on left ventricular remodelling after reperfused acute myocardial infarction. Heart 2003; 89: 393-7 Feldman LJ, Coste P, Furber A, Dupouy P, Slama MS, Monassier JP, Tron C, Lafont A, Faraggi M, Le Guludec D, Dubois-Rande JL, Steg PG. Incomplete resolution of ST-segment elevation is a marker of transient microcirculatory dysfunction after stenting for acute myocardial infarction. Circulation 2003 Jun 3 2003; 107: 2684-9. Aptecar E, Lecorvoisier P, Teiger E, Garot P, Dupouy P, Sediame S, Vermes E, Loisance D, Hittinger L, Dubois-Rande JL. Coronary vasomotor response to the selective B1-kinin-receptor agonist Des-Arg9-bradykinin in humans. J Heart Lung Transplant. 2006;25:187-94. Obame FN, Plin-Mercier C, Assaly R, Zini R, Dubois-Randé JL, Berdeaux A, Morin D. Cardioprotective effect of morphine and a blocker of glycogen synthase kinase 3 beta, SB216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione], via inhibition of the mitochondrial permeability transition pore. J Pharmacol Exp Ther. 2008 Jul;326(1):252-8.

Why should you be elected? (25 lines words max)?

I have an active experience as treasurer (national and International) so I can give time and share this expertise for the EAPCI. I would be honoured to participate to the different teaching programs since I am involved in France and more recently in Europe. I think that a lot of work is necessary to homogenize practice in the different EU countries. While serving in a University, I can share my expertise with the different research programs of the association