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Study of glycemic profile of Cajanus cajan leaves in experimental rats

Dolly Jaiswal, Prashant Kumar Rai, Amit Kumar & Geeta WatalAlternative Therapeutics Unit, Drug Development Division, Medicinal Research Lab,

Department of Chemistry; University of Allahabad, Allahabad 211 002 (U.P.)

Abstract

Cajanus cajan K (Millsp) is commonly known as pigeon pea (or red gram). It is an important pulse crop of the tropicalregions. The present study deals with the aqueous extract of Cajanus cajan leaves and evaluation of its glycemic profile inStreptozotocin induced type-2 diabetic rats. Single oral administration of graded doses of aqueous extract of leaves showedsignificant increase in fasting blood glucose levels (FBG) of normal rats by 14.3%. The mild diabetic and sub-diabeticanimals had shown hyperglycemic effect from variable doses of extract. The maximum rise of 17.0, 71.3 and 50.8 % was

observed in BGL from a dose of 1000 mglkg body weight after administration in normal, sub and mild diabetic rats,respectively during glucose tolerance test (GTT). The study of leaves was taken into consideration on the basis of earlierreported hypoglycemic activity of Cajanus cajan seeds. However, the results observed were found just opposite andtherefore it may be useful in controlling hypoglycemia, occasionally caused due to excess of insulin and other

hypoglycemic drugs.

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1549-1600.

2. cRrtt Q; 'fl, :r:<IT \31R cFi~ crroo;;ft, Cif#r Jttrli T:[H1wifc5Ji'lMI,97(2) (2005) 247-25\.

3. :r:<IT \31R cFi, cRJiT Q; 'fl, 'Wf eft em, ~ \31R ~ crroo ;;ft,Cif#r Jttr:n <[HI Wifcili'lTvfI, 99 (2005), 75-8\.

4. ::frcR \if cFi, IJTG:Cf em ~ C[(B cIT, Cif#r Jttr:n T:[&f)l/JfiTc5Ji'lMJ,81 (2002) 81-100.

5. ¢m ~ gr, <;<:IT ~ ~ fcrc;r;r Q;, Cif#r Jttr:n T:[&f)wifc5Ji'lMI,27 (1989) 243-275.

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(1984) 645

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10. ~ W Q;, BP1TQ; ~, vr#r Jttr:n T:[~;j)wifC/?)i'lTvfI,8 (1983

215-223.

II. ;;fr~ft ~ gr ~ futR;r eft W, ~ ~ vr#r Jttr:n ~$'-'

[[US sI4RJt2em, 19 (1982) 337.

12. ~ if ~ ~~ em, ~ vr#r Jttr:n QemiJf!ilU2(

illdli'lTvfI, 36 (10) (1998) .1032-1033.

13. \31~TIcn eft ;;ft, ~ em cFi, wi/de1Jf?t,?r:7, 47(2) (1991

197-202.

14. we::r gr ~ ~ eft, ~ 97 (1972) 412-415.