Pr bouchard

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  • 1. Charles Edouard Brown Sequard (1817- 1894)

2. Science 1997 3. & GH 4. GH-IGF1-Insulin

  • 1- Les donnes de la recherche sont sans equivoque.

5. INSULIN/ IGFsSignaling 6. INSULIN/ IGFsSignaling KO GH KO GHRH KO GHR KO KO IGF1 KO IGF1-R KO IRS 1 & 2, PI3 K Yeasts, caenorhabditis elegans, insects, mice& centenarial model 7. Endocrine Reviews 2011 8. Des taux bas d IGF1 sont associs une longvit accrue

  • Dficit en GH
  • KO des rcepteurs de la GH
  • KO des rcepteurs de l IGF1(Bartke A Cur Top Dev Biol 63:189, 2004)

9. 10. 11. 12. 13. 14. + 18 % 15. 16. GH-IGF1-Insulin

  • 2- Chez lhomme

17. 18. Endocrine Reviews 2010, 31: 301-342. 19. 20. JCEM 18: 901- 903, 1958 NATURE 1979 21. There is now a substantial body of evidence that indicates thatGH Replacement Therapy has a beneficial effect upon many parameters: Body composition improves, lean mass increases, and fat mass decreases sgnificantly.

  • Fasting lipid profile improves with reduction on total cholesterol, LDL
  • while HDL increases.
  • GHT improves endothelial function as well as the markers of inflammation
  • - Carotid IMT also demonstrates a significant improvement during therapy

22. Swerdlow AJ, Higgins CD, Adlard P, Preece MA2002 Risk of cancer in patients treated with 17 human pituitary growth hormone in the UK, 1959-85: a cohort study. Lancet 360:273-277

  • Insulin resistance is Increased
  • There is no data demonstrating
  • that GHT reduces cardiovascular mortality
  • in hypopituitary adults
  • - In addition: cancer risk may be increased

HOWEVER 23. JCEM 2012 SAGhE:Safety and Appropriateness of Growth hormone treatments in Europe 24. 25. 26. 27. 28. 29. Les Fondamentaux

  • Apprends dhier, vis pour aujourdhui, espre pour demain.
  • Limportant est de ne jamais arrter de poser des question.
  • Albert Einstein

30. www.ice-ece2012.com