Major changes in men with non-small-cell lung cancer...
Transcript of Major changes in men with non-small-cell lung cancer...
KBP-2010 - 1
Major changes in men with non-small-cell lung cancer (NSCLC) in 10 years: the KBP-2000-CPHG and KBP-2010-CPHG cohorts
Didier Debieuvre, Mulhouse
Chrystèle Locher (Meaux), Sylvie Vuillermoz-Blas (Lyon), Jacky Crequit (Creil), Edith Maetz (Douai), Anne Brichet-Martin
(Roubaix), David Renault (Morlaix), Jean-Yves Le Tinier (Bligny), Gérard Oliviero (Longjumeau), Jérôme Virally (Aulnay),
Sébastien Larive (Macon), Michel Grivaux (Meaux)
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Conflicts of Interest
Employment or Leadership Position: None
Consultant or Advisory Role: None
Stock Ownership: None Honoraria: None Research Funding: Roche, AstraZeneca, Amgen, Lilly, AB sciences, Transgene,
Stallergene, BMS, Boehringer Ingelheim, Chugai, Pierre Fabre, Pfizer, MSD, Novartis, GSK, Sanofi Aventis
Expert Testimony: AstraZeneca, Novartis, Vifor, Roche, Boehringer Ingelheim Patents: None Other Remuneration (Invited Conferences and Congress):
AstraZeneca, Amgen, Janssen, Lilly, Roche, GSK, Sanofi Aventis, Pierre Fabre, MSD, Boehringer Ingelheim, Novartis, Pfizer
è No real or perceived, conflicts of interest that relate to this oral presentation.
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Introduction
• Background: - In 2000 and 2010, the CPHG performed KBP-2000-CPHG and
KBP-2010-CPHG, 2 prospective multicentre cohort studies that included 1 in 5 primary lung cancers diagnosed in France in 2000 and 2010.
- These studies confirmed the change in patients’ and lung cancer characteristics: more women, never-smokers, and adenocarcinomas.
• Objective: - To review the evolution of NSCLC characteristics in male patients in 10 years.
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2000 2010 Sponsor: • French College of General Hospital Respiratory Physicians (CPHG)
Scientific committee:
• Chairman
• Scientific secretaries
• Other members
• F. Blanchon, Meaux
• T. Collon, Montfermeil • M. Grivaux, Meaux
• H. Barbieux, Roubaix • M. Bénichou-Flurin, Pau • J.-L. Breton, Belfort • D. Coëtmeur, St-Brieuc • B. Delclaux, Troyes • J. Piquet, Montfermeil
• M. Grivaux, Meaux
• C. Locher, Meaux • D. Debieuvre, Mulhouse
• B. Asselain, Paris • F. Blanchon, Meaux • D. Coëtmeur, St-Brieuc • T. Collon, Montfermeil • C. Dayen, St-Quentin • F. Goupil, Le Mans • J. Le Treut, Aix en Provence • F. Martin, Compiègne • O. Molinier, Le Mans
Study centres: Investigators:
• Respiratory medicine departments in a general hospital • Physicians practicing in the respiratory medicine department
Organisation
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Methods
• Inclusion criteria: ü Age ≥ 18 years, ü Primary lung cancer diagnosed histologically or cytologically
from 01-Jan-2000 to 31-Dec-2000 and from 01-Jan-2010 to 31-Dec-2010 (date of sampling),
ü Followed-up in the respiratory department of one of the participating French general hospitals,
ü Oral informed consent.
• A standardised form was completed for each patient.
• Collected data: patient characteristics and tumour characteristics and management at inclusion.
• A steering committee checked recruitment exhaustiveness in each centre and all centres together.
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Study population
KBP-2000-CPHG
Centres: 137 Patients: 5667 (N ≈ 41/centre)
NSCLC: 4720 (N ≈ 34/centre)
Male: 3921 (N ≈ 29/centre)
KBP-2010-CPHG
Centres: 104 Patients: 7051 (N ≈ 68 /centre)
NSCLC: 6101 (≈ 59/centre)
Male: 4597 (N ≈ 44/centre)
In 2000, 83.1% of men among NSCLC patients
In 2010, 75.3% of men among NSCLC patients
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Age at diagnosis
64.4 years in 2000 vs. 65.7 years in 2010 (p < 0.0001)
p < 0.0001
% of male patients
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Smoking
p < 0.0001
Former-smokers, cessation: 11 years in 2000 vs. 15.3 years in 2010 % of male patients
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Tumour stage % of male patients
p < 0.0001
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Histology % of male patients
N: mean number of cases of NSCLC in male patients diagnosed in each centre
p < 0.0001
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Occupational exposure % of male patients
p < 0.0001
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First therapeutic strategy
p < 0.0001 p = 0.04
p < 0.0001
p = 0.02
% of male patients
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• Male patients’ and lung cancer characteristics have changed in 10 years: - Patients are older and more frequently never-smoker - Tumour are more frequently metastatic or extended - Adenocarcinoma is the most frequently reported histology in 2010
• NSCLC is still a men disease (75.3%) and a smoker disease (49%).
• In daily clinical practice, the number of squamous-cell carcinomas diagnosed in the respiratory departments of the French general hospitals remains stable.
• The increase of adenocarcinoma in male patients reflects possibly the emergence of a “new” lung cancer. This hypothesis deserves further analysis.
Conclusion
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Aknowledgments
Created in January 2010 (SPLF, CPHG, FFP, …)
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Investigators CENTRES INVESTIGATEURS CENTRES INVESTIGATEURS CENTRES INVESTIGATEURS Abbeville O LELEU Douai E MAETZ Morlaix D RENAULT Aix-en-Provence J LE TREUT Draguignan J-R BARRIERE Moulins H BELHADJ Albi B BORREL Dreux F MARTIN Mulhouse P BOMBARON Angoulême-Saint-Michel M MARTIN Eaubonne F DENIEL Nanterre M SAILLOUR Annecy S HOMINAL Elbeuf-Louviers-Val-de-Reuil P DAVID Nevers D HERMAN Antibes-Juan-Les-Pins C MOUROUX-ROTOMONDO Epernay M CARBONNELLE Niort M D ARLHAC Argentan C DUBOS-ARVIS Epinal J-L COLLIGNON Nouméa-Nouvelle-Calédonie G FESQ Argenteuil H DE CREMOUX Evreux H MAHMOUD Oloron-Sainte-Marie E DE GROOTE Arras Y LIERMAN Fougères A MERZOUG Orléans B LEMAIRE Aubagne M IRISSON Fréjus-Saint-Raphaël D BOUDOUMI Paimpol G PERRUS Aubenas P DION Gap P THOMAS Papeete-Tahiti P FERRER LOPEZ Aulnay-sous-Bois J VIRALLY Granville-Avranches V TIZON Paray-le-Monial C GENETY Auxerre H BARBIEUX Grasse M FIGUEREDO Pau P-A RENAULT Bar-le-Duc P TAGU Guingamp K BADOUR Périgueux S LACROIX Bastia-Furiani J-C MOURIES Hénin-Beaumont E FOURNIER Perpignan D CHOMA Bayonne J-P MATHIEU Lagny-sur-Marne A BEDOSSA Pontoise G FRABOULET Belfort-Montbeliard D DEBIEUVRE La-Rochelle D LEMERRE Quimper H GALLOUX Bergerac L PORTEL La-Roche-sur-Yon J BERRUCHON Rodez S JULIEN Béziers F GOUTORBE Le-Chesnay-Versailles C DUJON Roubaix F STEENHOUWER Bourg-en-Bresse P BEYNEL Le-Coudray-Chartres O RAFFY Saint-Brieuc D COETMEUR Bourges G ADAM Le-Havre M PEUREUX Sainte-Feyre S JEANDEAU Bourgoin-Jallieu B GENTIL LE PECQ Le-Mans F GOUPIL Saint-Germain-en-Laye-Poissy S JOUVESHOMME Briey B REMIGNON Lens O FLOREA Saint-Malo E GOARANT Briis-sous-Forges-Bligny J-Y LE TINIER Libourne J-M MARCOS Saint-Nazaire D SANDRON Cahors P BARRE Longjumeau G OLIVIERO Saint-Pierre-Réunion F PAGANIN Cannes Y DUVAL Lons-le-Saunier M PERRICHON Saint-Quentin E LECUYER Chalons-en-Champagne G BERTHIOT Lourdes J-P VABRE Salon-de-Provence B KASSEYET-KALUME Chambéry V FRAPPAT Lyon-Desgenettes J-M DOT Saverne F BROLLY Charleville-Mézières S CHOUABE Lyon-St-Joseph-St-Luc S VUILLERMOZ-BLAS Sedan G-J KASSEM Chateauroux F LAMOTTE Mâcon S LARIVE Soissons M-G LEGRAND-HOUGNON Chaumont B SIMON Mantes-la-Jolie J-B AULIAC Thionville P BOTRUS Chauny P DUMONT Martigues M BELKAÏD Thonon-Les-Bains P ROMAND Chevilly-Larue K DE LUCA Meaux C LOCHER Troyes B DELCLAUX Cholet P MASSON Melun J-P DI MERCURIO Valence R RIOU Colmar J-P OSTER Metz N PAILLOT Vesoul D DEBIEUVRE Compiègne S DEHETTE Meulan-les-Mureaux E LEROY-TERQUEM Vienne C MARICHY Corbeil-Essonnes O SALMON Montargis T BENAICHA Villefranche-sur-Saône L FALCHERO Creil P LE LANN Montélimar B DUVERT Villenave-d’Ornon A CUGUILLIERE Dinan C BERNIER Montfermeil-Le-Raincy T COLLON Villeneuve-Saint-Georges C FOURET Mont-Saint-Martin R RANGASAMY Villeneuve-sur-Lot A RAZAFINDRAMBOA
Special thanks to: Margaux Orange team, Patients and their Families