II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch...

43
BI 121 Lecture 16 I. Announcements Notebooks? Exam II, Dec 13 th Friday 8 am. Review session in class next Thurs. Q? II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. Summary of skeletal muscle contraction Malcolm Campbell & David Bolinsky videos B. Exercise adaptation variables: mode, intensity, duration, frequency, distribution, individual & environmental char...? C. Endurance vs. strength training continuum? fiber types... III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal? LS fig 12-1 pp 345-347 B. Respiratory anatomy LS fig 12-2 p 347, DC, Fox +... C. Histology LS fig 12- 4 pp 347-349, DC D. How do we breathe? LS fig 12-12, fig 12-25 pp 349-356, pp 373-378 We're on a roll! Bring on Exam II!

Transcript of II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch...

Page 1: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

BI 121 Lecture 16

I. Announcements Notebooks? Exam II, Dec 13th

Friday 8 am. Review session in class next Thurs. Q?

II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12

A. Summary of skeletal muscle contraction

Malcolm Campbell & David Bolinsky videos

B. Exercise adaptation variables: mode, intensity, duration,

frequency, distribution, individual & environmental char...?

C. Endurance vs. strength training continuum? fiber types...

III.Respiratory System LS ch 12, DC Module 7, Fox +...

A. Steps of respiration? External vs. cellular/internal?

LS fig 12-1 pp 345-347

B. Respiratory anatomy LS fig 12-2 p 347, DC, Fox +...

C. Histology LS fig 12- 4 pp 347-349, DC

D. How do we breathe? LS fig 12-12, fig 12-25 pp 349-356,

pp 373-378

We're on a roll! Bring on Exam II!

Page 2: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Be safe in travel! Peace!Have a Happy Turkey Day!!!

Page 3: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?
Page 4: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Adaptations to Exercise?Body Levels of Organization?

Which Body System?

Molecular

Cell/Tissue

Organ

Body System

Page 5: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Muscle

Adaptations

to Exercise

Page 6: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

As muscles tug on bones, bones get stronger, too!...many systems adapt!!

Page 7: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Echocardiography documents hypertrophy...

LA

LV

RV

[RA]

LA

LV

[RA]

RV

Page 8: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Cardiac Adaptations to Exercise:

Endurance vs. StrengthTraining1 2

1

1 2+

NB: > LBM1

2

Page 9: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Atrophy Hypertrophydecrease in size& strength

increase in size& strength

Page 10: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Atrophy

Skeletal Muscle

Page 11: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Women & Hypertrophy?

Page 12: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

What happens in muscles at cellular & subcellular levels?

Page 13: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Hypertrophy: Increased

Number of Myofibrils

Thick & Thin Filaments

Myosin & Actin Molecules

Myofibril

Page 14: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?
Page 15: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

LS 2012 tab 8-1 modified > VP Lombardi 1989

Characteristics of Skeletal Muscle Fibers

TYPE OF FIBERSlow Oxidative Fast Oxidative Fast Glycolytic(Type I) (Type IIa) (Type IIb)Characteristic

Myosin-ATPase Activity Low High High

Speed of Contraction Slow Fast Fast

Resistance to Fatigue High Intermediate Low

Aerobic Capacity High High Low

Anaerobic Capacity Low Intermediate High

Mitochondria Many Many Few

Capillaries Many Many Few

Myoglobin Content High High Low

Color of Fibers Red Red White

Glycogen Content Low Intermediate High

Page 16: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?
Page 17: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Muscle Changes Due to Strength Training

Size of larger fast vs smaller slow fibersCP as well as creatine phosphokinase (CPK)which enhances short-term power outputKey enzymes which help store and dissolve sugar including glycogen phosphorylase (GPP) & phosphofructokinase (PFK)

Mitochondrial # relative to muscle tissue

Vascularization relative to muscle tissueSplitting of fast fibers? Hyperplasia?With growth hormone (GH), androgenic-anabolic steroids (AAS)?

Page 18: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Muscle Changes Due to Endurance Training

Mitochondria, # & sizeMitochondrial (aerobic) enzymesincluding those specific for fat burning

Vascularization of muscles (better blood flow)

Stores of fat in muscles accompanied by

Triglycerides/fats in bloodstreamEnzymes: activation, transport,breakdown (-oxidation) of fatty acids

Myoglobin (enhances O2 transport)Resting energy levels which inhibitsugar breakdown

Aerobic capacity of all three fiber types.

Page 19: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Which end of

continuum?

+

Which energy

nutrient/s?

Page 20: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

+ Which specific muscles?

Page 21: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?
Page 22: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?
Page 23: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Dancing can be super aerobic exercise, too,& you don’t have to be a star!

Page 24: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Extremes of the energy continuum!

Page 25: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Discussion + Time for Questions!

Page 26: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?
Page 27: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

1 Breathe in & out!

2 Cross membranes!

4 Cross membranes!

3 Move with blood!

Go with the flow!

Lombo’s simplified steps!

LS 2012 fig 12-1 modified

Page 28: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Respiratory System Anatomy

LS 2012 fig 12-2

NB: In vivo, Cupola or peak of each lung goes into neck > clavicle line!

Page 29: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

16-20 C-shaped bars

of hyaline cartilage to

prevent collapse

DC 2003

Page 30: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

DC 2003

Vocal cords approximate (move

closer together) during Valsalva's maneuver!

Page 31: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Pulmonary Latex Cast with Colored Segmentation

Page 32: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Bronchograms (posteroanterior)

Source: Gardner, Gray, O’Rahilly, Anatomy, fig 29-11, p 295.

R L

Page 33: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

No Gas Exchange

Gas Exchange

1st alveolar outpouching!

Co

nd

ucti

ve Z

on

eR

es

pir

ato

ry Z

on

e

SI Fox

Page 34: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?
Page 35: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?
Page 36: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Alveoli

SI Fox

Page 37: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

L Brilla 1983

Alveoli White Blood Cell

Capillaries with rbcs!

Page 38: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Muscles of Ventilation

LS 2012 fig 12-11

NB: Diaphragm is the

chief muscle of

ventilation!

Page 39: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Inhale (active) Exhale (passive @ rest)

Contract & flatten diaphragm Relax & pouch up diaphragm!

Page 40: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

LS 2012 fig 12-25

Brain stem ≡ Control Center for automatic

breathing!

Page 41: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Respiratory membraneseparates air from blood, is 6 layers, yet 1/50th

thickness of tracing paper!

LS 2012 fig 12-4acf: DC 2013 fig 7-4

Page 42: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

Alveoli are surrounded by jackets of capillaries!

LS 2012 fig 12-4b

Page 43: II. Muscle Contraction & Adaptation LS ch 8, DC Mod 12 A. …€¦ · III.Respiratory System LS ch 12, DC Module 7, Fox +... A. Steps of respiration? External vs. cellular/internal?

O2 HIGH

O2 LOWCO2 HIGH

CO2 LOW

cf: LS 2012 fig 12-19

Gas Exchange